Circulating long noncoding RNAs as potential biomarkers for stomach cancer: a systematic review and meta-analysis

Abstract Background Recent researches have suggested that long noncoding RNA (lncRNA) is involved in the tumorigenesis and development of stomach cancer (SC). This meta-analysis aimed to identify diagnostic performance circulating lncRNAs SC. Methods All relevant studies were systematically searched through PubMed, Web Science, Cochrane Library, EMBASE databases. The values mainly assessed by pooled sensitivity, specificity, summary receiver operating characteristic area under curve (SROC AUC). Meta-DiSc 1.4, Review Manager 5.3, STATA 12.0 used for statistical analysis. protocol this systematic review was registered on INPLASY (INPLASY202120079) available full inplasy.com ( 10.37766/inplasy2021.2.0079 ). Results A total 42 eligible included meta-analysis. SROC AUC 0.78 (95%CI 0.75–0.81), 0.75 0.71–0.78), 0.83 0.80–0.86), respectively, suggesting test had a high accuracy diagnosis Obvious heterogeneity might come from type lncRNA subgroup meta-regression Fagan diagram shows clinical value Conclusions Abnormal expression exhibits efficacy diagnosing SC, which promising application.